Article
Complementation of a herpes simplex virus ICP0 null mutant by varicella-zoster virus ORF61p.
Journal of virology - 1 Oct 2009
Kyratsous Christos A, Walters Matthew S, Panagiotidis Christos A, Silverstein Saul J
Abstract excerpt
The herpes simplex virus (HSV) ICP0 protein acts to overcome intrinsic cellular defenses that repress viral alpha gene expression. In that vein, viruses that have mutations in ICP0's RING finger or are deleted for the gene are sensitive to interferon, as they fail to direct degradation of promyelocytic leukemia protein (PML), a component of host nuclear domain 10s. While varicella-zoster virus is also insensitive...
Topics
- Antigens, Nuclear
- Autoantigens
- Cell Line, Tumor
- Gene Deletion
- Genetic Complementation Test
- Herpesvirus 3, Human
- Humans
- Immediate-Early Proteins
- Interferon-alpha
- Mutation
- Nuclear Proteins
- Promyelocytic Leukemia Protein
- Recombination, Genetic
- Simplexvirus