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Article

The immediate-early protein, ICP0, is essential for the resistance of herpes simplex virus to interferon-alpha/beta.

Virology - 15 Feb 2002

Härle Peter, Sainz Bruno, Carr Daniel J J, Halford William P

Abstract excerpt

Herpes simplex virus type 1 (HSV-1) is resistant to the antiviral effects of interferon (IFN)-alpha, -beta, or -gamma. The fact that ICP0(-) mutants replicate like wild-type virus in IFN-alpha/beta receptor knockout mice (Leib et al., 1999, J. Exp. Med. 189, 663) suggested that ICP0 may serve a direct role in the resistance of HSV-1 to IFN. To test this hypothesis, the effects of IFN-alpha, -beta, and -gamma were...

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Identifiers

PMID: 11886249
DOI: 10.1006/viro.2001.1280

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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