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Article

Herpes simplex ICP27 mutant viruses exhibit reduced expression of specific DNA replication genes.

Journal of virology - 1 Mar 1996

Uprichard S L, Knipe D M

Abstract excerpt

Herpes simplex virus type 1 mutants with certain lesions in the ICP27 gene show a 5- to 10-fold reduction in viral DNA synthesis. To determine how ICP27 promotes amplification of viral DNA, we examined the synthesis, accumulation, and stability of the essential viral replication proteins and steady-state levels of the replication gene transcripts throughout the course of ICP27 mutant virus infections. These...

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Identifiers

PMID: 8627723
DOI: 10.1128/JVI.70.3.1969-1980.1996
PMCID: PMC190026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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