Herpes simplex ICP27 mutant viruses exhibit reduced expression of specific DNA replication genes.

doi:10.1128/JVI.70.3.1969-1980.1996

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Article

Herpes simplex ICP27 mutant viruses exhibit reduced expression of specific DNA replication genes.

Journal of virology - 1 Mar 1996

Uprichard S L, Knipe D M

Abstract excerpt

Herpes simplex virus type 1 mutants with certain lesions in the ICP27 gene show a 5- to 10-fold reduction in viral DNA synthesis. To determine how ICP27 promotes amplification of viral DNA, we examined the synthesis, accumulation, and stability of the essential viral replication proteins and stea...

Topics

Animals
Cell Line
Chlorocebus aethiops
DNA Helicases
DNA Primase
DNA, Viral
Gene Expression Regulation, Viral
Herpesvirus 1, Human
Humans
Immediate-Early Proteins
Mutation
RNA, Messenger
RNA, Viral
Vero Cells
Viral Proteins
Virus Replication

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