Potential role for herpes simplex virus ICP8 DNA replication protein in stimulation of late gene expression.

doi:10.1128/JVI.65.5.2666-2675.1991

Back to search

Article

Potential role for herpes simplex virus ICP8 DNA replication protein in stimulation of late gene expression.

Journal of virology - 1 May 1991

Gao M, Knipe D M

Abstract excerpt

We have identified a trans-dominant mutant form of the herpes simplex virus (HSV) DNA-binding protein ICP8 which inhibits viral replication. When expressed by the V2.6 cell line, the mutant gene product inhibited wild-type HSV production by 50- to 150-fold when the multiplicity of infection was l...

Topics

Animals
Blotting, Western
Cell Line
DNA Replication
DNA, Viral
DNA-Binding Proteins
Fluorescent Antibody Technique
Gene Expression Regulation, Viral
Phenotype
Simplexvirus
Vero Cells
Viral Proteins
Virus Replication

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.