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Article

Potential role for herpes simplex virus ICP8 DNA replication protein in stimulation of late gene expression.

Journal of virology - 1 May 1991

Gao M, Knipe D M

Abstract excerpt

We have identified a trans-dominant mutant form of the herpes simplex virus (HSV) DNA-binding protein ICP8 which inhibits viral replication. When expressed by the V2.6 cell line, the mutant gene product inhibited wild-type HSV production by 50- to 150-fold when the multiplicity of infection was less than 5. Production of HSV types 1 and 2 but not production of pseudorabies virus was inhibited in V2.6 cells. The...

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Identifiers

PMID: 1850040
DOI: 10.1128/JVI.65.5.2666-2675.1991
PMCID: PMC240625

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Potential role for herpes simplex virus ICP8 DNA replication protein in stimulation of late gene expression.PMID 1850040Read ↗

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Identification of sequences in herpes simplex virus type 1 ICP22 that influence RNA polymerase II modification and viral late gene expression.Semantic proximity Read ↗

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Construction and characterization of a replication-defective herpes simplex virus 2 ICP8 mutant strain and its use in immunization studies in a guinea pig model of genital disease.Semantic proximity Read ↗

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