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Article

ICP4-induced miR-101 attenuates HSV-1 replication

17 Mar 2016

Abstract excerpt

Hepes simplex Virus type 1 (HSV-1) is an enveloped DNA virus that can cause lytic and latent infection. miRNAs post-transcriptionally regulate gene expression, and our previous work has indicated that HSV-1 infection induces miR-101 expression in HeLa cells. The present study demonstrates that HSV-1-induced miR-101 is mainly derived from its precursor hsa-mir-101-2, and the HSV-1 immediate early gene ICP4...

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PMID: 26984403
DOI: 10.1038/srep23205

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