Article
Ultrastructural changes related to multidrug resistance in CEM cells: role of cytoplasmic vesicles in drug exclusion.
Journal of experimental therapeutics & oncology - 1 Jan 1996
Bobichon H, Colin M, Depierreux C, Liautaud-Roger F, Jardillier J C
Abstract excerpt
The multidrug resistance phenotype is found to be frequently associated with the overexpression of proteins which lead to a decrease of drug accumulation within human tumor cells. A 170 kDa membrane glycoprotein which is related to the overexpression of the mdr1 gene is inserted in the plasma mem...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Cell Nucleolus
- Cell Nucleus
- Cytoplasm
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Genes, MDR
- Golgi Apparatus
- Humans
- Image Cytometry
- Leukemia, Lymphoid
- Lysosomes
- Microscopy, Electron
- Microscopy, Electron, Scanning
- Pharmaceutical Preparations
- Phenotype
- Tumor Cells, Cultured