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Article

Multidrug resistance in oncology: diagnostic and therapeutic approaches

1 Jun 1999

Abstract excerpt

Resistance to anticancer drugs is often mediated by the overexpression of a membrane pump able to extrude many xenobiotics out of the tumour cells. The most frequently expressed of these pumps is called P-glycoprotein and is encoded by a gene called MDR1 (for multidrug resistance). There could be great clinical interest for investigating the expression of this gene or of its product in patients' tumours, as well...

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Identifiers

PMID: 10354216
DOI: 10.1046/j.1365-2362.1999.00495.x

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