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Article

Mechanisms of multidrug resistance in cancer treatment.

Acta oncologica (Stockholm, Sweden) - 1 Jan 1992

Harris A L, Hochhauser D

Abstract excerpt

Advanced breast cancer responds to a range of cytotoxic agents, but resistance always develops. Understanding the mechanisms of resistance may provide new therapeutic options. There are several major groups of resistance mechanisms. 1) The multidrug resistant phenotype. This is due to a membrane pump that can extrude a wide range of anticancer drugs--the P-glycoprotein. It is inhibited by a range of clinically...

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PMID: 1352455
DOI: 10.3109/02841869209088904

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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