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Article

Genetic instability leads to loss of both p53 alleles in a human glioblastoma.

Oncogene - 22 Jan 1998

Albertoni M, Daub D M, Arden K C, Viars C S, Powell C, Van Meir E G

Abstract excerpt

Little is known about the relationship between genetic recombination mechanisms and loss of tumour suppressor genes in solid tumours. Here, we demonstrate deletion and truncation of both p53 alleles in a primary human glioblastoma and a derived cell line as the combined result of a t(17;20) reciprocal translocation and a 1.1 Mbp genomic deletion on chromosome 17p, starting in intron 4 of the p53 gene and ending...

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Identifiers

PMID: 9467957
DOI: 10.1038/sj.onc.1201544

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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