Genetic instability leads to loss of both p53 alleles in a human glioblastoma.

doi:10.1038/sj.onc.1201544

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Article

Genetic instability leads to loss of both p53 alleles in a human glioblastoma.

Oncogene - 22 Jan 1998

Albertoni M, Daub D M, Arden K C, Viars C S, Powell C, Van Meir E G

Abstract excerpt

Little is known about the relationship between genetic recombination mechanisms and loss of tumour suppressor genes in solid tumours. Here, we demonstrate deletion and truncation of both p53 alleles in a primary human glioblastoma and a derived cell line as the combined result of a t(17;20) recip...

Topics

Alleles
Base Sequence
Brain Neoplasms
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 20
DNA, Complementary
DNA, Neoplasm
Exons
Gene Deletion
Genes, p53
Glioblastoma
Humans
In Situ Hybridization, Fluorescence
Molecular Sequence Data
Polymerase Chain Reaction
Translocation, Genetic
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 9467957
DOI: 10.1038/sj.onc.1201544

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9467957-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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