Ablation of stimulation of a cAMP-responsive promoter in CHO cell lines defective in their cAMP-dependent protein kinase system.

doi:10.1007/BF01233157

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Article

Ablation of stimulation of a cAMP-responsive promoter in CHO cell lines defective in their cAMP-dependent protein kinase system.

Somatic cell and molecular genetics - 1 Mar 1992

Fleischmann R D, Jeng C, Gottesman M M

Abstract excerpt

We have studied the requirement for an intact cAMP-dependent protein kinase (PKA) system to regulate cAMP-mediated gene transcription in Chinese hamster ovary (CHO) cells. Wild-type CHO cells and mutant CHO cell lines selected for their resistance to the growth inhibitory effect of 8-Br-cAMP and...

Topics

8-Bromo Cyclic Adenosine Monophosphate
Animals
CHO Cells
Chloramphenicol O-Acetyltransferase
Cricetinae
Cyclic AMP
Gene Expression Regulation
Mutation
Plasmids
Promoter Regions, Genetic
Protein Kinases
Tyrosine Transaminase

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PMID: 1349445
DOI: 10.1007/BF01233157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1349445-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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