Non-phenotypic selection of N-methyl-N-nitrosourea-induced mutations in human cells.

doi:10.1093/nar/20.6.1349

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Article

Non-phenotypic selection of N-methyl-N-nitrosourea-induced mutations in human cells.

Nucleic acids research - 25 Mar 1992

Palombo F, Bignami M, Dogliotti E

Abstract excerpt

The distribution of mutations in a particular gene as detected by a selective mutation assay could be affected by the structural properties of the target protein. To investigate this, we have analysed N-methyl-N-nitrosourea (MNU)-induced mutations in two restriction recognition sequences of a tar...

Topics

Base Sequence
Cell Line
DNA
Deoxyribonucleases, Type II Site-Specific
Genotype
Humans
Methylnitrosourea
Molecular Sequence Data
Mutation
Pentosyltransferases
Phenotype
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length

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