Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Restriction fragment pattern analysis of HPRT mutations induced in rat-liver epithelial cells by alkylating and arylating agents.

Mutation research - 1 Feb 1992

Alvi N K, Williams G M

Abstract excerpt

Structural alterations in the hypoxanthine-guanine phosphoribosyl transferase (HPRT) gene in genomic DNA of adult rat-liver (ARL) epithelial cells that were mutated by alkylating and arylating mutagens were studied by restriction enzyme fragment pattern (RFP) analysis. ARL cells were mutated with the direct-acting alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or the activation-dependent arylating...

Topics

2-Acetylaminofluorene
9,10-Dimethyl-1,2-benzanthracene
Alkylating Agents
Animals
Blotting, Southern
Cell Line
Epithelial Cells
Epithelium
Hypoxanthine Phosphoribosyltransferase
Liver
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Methylnitronitrosoguanidine

Mutation

Polymorphism, Restriction Fragment Length

Rats

Rats, Inbred F344

Source

Identifiers

PMID: 1370727
DOI: 10.1016/0027-5107(92)90057-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1370727-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Restriction fragment pattern analysis of HPRT mutations induced in rat-liver epithelial cells by alkylating and arylating agents.PMID 1370727Read ↗

Molecular characterization of mutations in the hprt gene of normal human skin keratinocytes treated with N-ethyl-N-nitrosourea: influence of O6-alkylguanine alkyltransferase.Semantic proximity Read ↗

Mutations and reduced expression of the transforming growth factor-beta receptor II gene in rat lung adenocarcinomas induced by N-nitrosobis-(2-hydroxypropyl)amine.Semantic proximity Read ↗

A novel signature mutation for oxidative damage resembles a mutational pattern found commonly in human cancers.Semantic proximity Read ↗

Acrylamide-induced molecular mutation spectra at HPRT locus in human promyelocytic leukaemia HL-60 and NB4 cell lines.Semantic proximity Read ↗

Kinds and location of mutations induced by (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in the coding region of the hypoxanthine (guanine) phosphoribosyltransferase gene in diploid human fibroblasts.Semantic proximity Read ↗

Sequence specificity of Hprt lymphocyte mutation in rats fed the hepatocarcinogen 2-acetylaminofluorene.Semantic proximity Read ↗

Hprt mutant frequency and molecular analysis of Hprt mutations in rats treated with mutagenic carcinogens.Semantic proximity Read ↗

Gene- and tissue-specificity of mutation in Big Blue rats treated with the hepatocarcinogen N-hydroxy-2-acetylaminofluorene.Semantic proximity Read ↗

Analysis of in vivo mutation in exon 8 of the rat hprt gene.Semantic proximity Read ↗

Mutagenic effects of poly (ADP-ribose) polymerase-1 deficiency in transgenic mice.Semantic proximity Read ↗

Endogenous gene systems for the study of mutational specificity in mammalian cells.Semantic proximity Read ↗

Aristolochic acid-induced carcinogenesis examined by ACB-PCR quantification of H-Ras and K-Ras mutant fraction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.