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Article

p53 gene alterations in prostate cancer after radiation failure and their association with clinical outcome: a molecular and immunohistochemical analysis.

Pathology, research and practice - 1 Jan 1999

Rakozy C, Grignon D J, Li Y, Gheiler E, Gururajanna B, Pontes J E, Sakr W, Wood D P, Sarkar F H

Abstract excerpt

This study evaluates the prevalence of p53 gene mutations in prostate cancer in salvage prostatectomies after radiation failure using single strand conformational polymorphism (SSCP) and direct sequencing of the polymerase chain reaction (PCR) product. Findings were correlated with immunohistochemically (IHC) detectable p53 expression in residual prostate cancer. The usefulness of p53 as a marker of clinical...

Topics

Aged
Disease-Free Survival
Genes, p53
Humans
Immunohistochemistry
Male
Middle Aged
Mutation
Neoplasm Recurrence, Local
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prostatectomy

Prostatic Neoplasms

Radiation Tolerance

Salvage Therapy

Treatment Failure

Source

Identifiers

PMID: 10220791
DOI: 10.1016/S0344-0338(99)80024-7

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