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Article

p53 immunohistochemical and genetic alterations are associated at high incidence with post-irradiated locally persistent prostate carcinoma.

The Journal of urology - 1 May 1996

Prendergast N J, Atkins M R, Schatte E C, Paulson D F, Walther P J

Abstract excerpt

PURPOSE: Several reports have shown that cells with p53 mutations display increased resistance to ionizing radiation, a treatment often used clinically for localized prostate carcinoma. MATERIALS AND METHODS: Totals of 18 post-irradiated locally recurrent prostatic carcinoma specimens and 25 (no radiation) stage D1 node-positive (TxN+MO) primary prostatic carcinoma specimens were tested for p53 immunoreactivity...

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Source

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PMID: 8627854

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Source receipt: pubmed, retrieved 7 Sept 2026.

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