Article
p53 immunohistochemical and genetic alterations are associated at high incidence with post-irradiated locally persistent prostate carcinoma.
The Journal of urology - 1 May 1996
Prendergast N J, Atkins M R, Schatte E C, Paulson D F, Walther P J
Abstract excerpt
PURPOSE: Several reports have shown that cells with p53 mutations display increased resistance to ionizing radiation, a treatment often used clinically for localized prostate carcinoma. MATERIALS AND METHODS: Totals of 18 post-irradiated locally recurrent prostatic carcinoma specimens and 25 (no...
Topics
- Adenocarcinoma
- Antibodies, Monoclonal
- Genes, p53
- Humans
- Immunohistochemistry
- Incidence
- Male
- Mutation
- Neoplasm Recurrence, Local
- Polymorphism, Single-Stranded Conformational
- Prostatic Neoplasms
- Retrospective Studies
- Treatment Failure