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Article

Gene conversion vs point mutation in generating variability at the antigen recognition site of major histocompatibility complex loci.

Journal of molecular evolution - 1 Aug 1995

Ohta T

Abstract excerpt

In order to assess the roles of gene conversion followed by natural selection and balancing selection for point mutations in polymorphisms at major histocompatibility complex (MHC) loci, DNA sequences of several mammalian taxa were analyzed. Synonymous and nonsynonymous diversities were estimated separately for the antigen recognition site (ARS) and the remaining region of class I and class II genes. In some...

Topics

Animals
Base Sequence
Cattle
Gene Conversion
Gene Frequency
Genes, MHC Class I
Genes, MHC Class II
Genetic Variation
Humans
Point Mutation
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rabbits

Selection, Genetic

Source

Identifiers

PMID: 7666440
DOI: 10.1007/BF00170662

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7666440-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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