Article
Gene conversion generates hypervariability at the variable regions of kallikreins and their inhibitors.
Molecular phylogenetics and evolution - 1 Jun 1992
Ohta T, Basten C J
Abstract excerpt
The two mechanisms for generating hypervariability at the reactive center of serine proteases and their inhibitors are gene conversion followed by natural selection and natural selection for point mutation. One way to clarify the effects of these two mechanisms is to calculate separately the number of nonsynonymous substitutions and that of synonymous substitutions at the variable regions and at the conserved...
Topics
- Animals
- Gene Conversion
- Genetic Variation
- Humans
- Kallikreins
- Mice
- Multigene Family
- Point Mutation
- Rats
- Selection, Genetic
- Serpins