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Article

Problems in using statistical analysis of replacement and silent mutations in antibody genes for determining antigen-driven affinity selection.

Immunology - 1 Oct 2005

Bose Biplab, Sinha Subrata

Abstract excerpt

The analysis of molecular signatures of antigen-driven affinity selection of B cells is of immense use in studies on normal and abnormal B cell development. Most of the published literature compares the expected and observed frequencies of replacement (R) and silent (S) mutations in the complementarity-determining regions (CDRs) and the framework regions (FRs) of antibody genes to identify the signature of...

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Identifiers

PMID: 16162266
DOI: 10.1111/j.1365-2567.2005.02208.x
PMCID: PMC1817819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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