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Article

[Somatic hypermutagenesis in immunoglobulin genes. II. Properties of somatic mutations and clonal selection].

Molekuliarnaia biologiia - 1 Jan 2000

Rogozin I B, Solov'ev V V

Abstract excerpt

Analysis of the collection of 203 somatic mutations in immunoglobulin genes was carried out. It was shown, that the high frequency of these mutations in CDRs of V-genes may be connected with the high concentration of repeats in these regions. In addition, the observed clusterization of mutations may emerge from simultaneous correction of several pertubations of complementarity in the heteroduplex, formed by the...

Topics

Amino Acids
Animals
B-Lymphocytes
Gene Expression Regulation
Genes, Immunoglobulin
Humans
Mutation
Repetitive Sequences, Nucleic Acid

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2788803

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2788803-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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