Article
A study of the effects of rifabutin on isoniazid pharmacokinetics and metabolism in healthy volunteers.
Drug metabolism and drug interactions - 1 Jan 1992
Breda M, Pianezzola E, Strolin Benedetti M, Efthymiopoulos C, Carpentieri M, Sassella D, Rimoldi R
Abstract excerpt
The effect of repeated administration of rifabutin on the pharmacokinetics and metabolism of isoniazid was evaluated in 6 healthy volunteers. The subjects received on day 1 and 9 a single oral dose of 300 mg isoniazid and from day 2 to 8 a single daily oral dose of 300 mg rifabutin. Two out of 6 subjects were shown to be rapid acetylators. No significant modification of the plasma pharmacokinetic profiles of...
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