A study of the effects of rifabutin on isoniazid pharmacokinetics and metabolism in healthy volunteers.

doi:10.1515/dmdi.1992.10.4.323

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Article

A study of the effects of rifabutin on isoniazid pharmacokinetics and metabolism in healthy volunteers.

Drug metabolism and drug interactions - 1 Jan 1992

Breda M, Pianezzola E, Strolin Benedetti M, Efthymiopoulos C, Carpentieri M, Sassella D, Rimoldi R

Abstract excerpt

The effect of repeated administration of rifabutin on the pharmacokinetics and metabolism of isoniazid was evaluated in 6 healthy volunteers. The subjects received on day 1 and 9 a single oral dose of 300 mg isoniazid and from day 2 to 8 a single daily oral dose of 300 mg rifabutin. Two out of 6...

Topics

Acetylation
Adult
Anti-Bacterial Agents
Chromatography, High Pressure Liquid
Half-Life
Humans
Isoniazid
Male
Phenotype
Rifabutin
Rifamycins
Spectrophotometry, Ultraviolet

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