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Article

Lowering of theophylline clearance by isoniazid in slow and rapid acetylators.

British journal of clinical pharmacology - 1 May 1990

Samigun, Mulyono, Santoso B

Abstract excerpt

The effect of isoniazid (INH) pretreatment (400 mg daily for 2 weeks) on the elimination kinetics of theophylline (given intravenously as aminophylline equivalent to 151.2 mg theophylline) was investigated in 13 healthy male non-smokers. Amongst the 13 subjects studied, seven were rapid and six were slow acetylators. The mean clearance of theophylline was significantly lowered after INH (2.20 +/- 0.24 l h-1)...

Topics

Acetylation
Adult
Half-Life
Humans
Isoniazid
Male
Middle Aged
Phenotype
Theophylline

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2350534
DOI: 10.1111/j.1365-2125.1990.tb03681.x
PMCID: PMC1380157

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2350534-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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