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Article

[Bioavailability of isoniazid in healthy volunteers--fast and slow INH acetylators].

Pneumonologia i alergologia polska - 1 Jan 2002

Augustynowicz-Kopeć Ewa, Zwolska Zofia, Niemirowska-Mikulska Hanna

Abstract excerpt

The major pathway for INH metabolism is acetylation of acetyloisoniazid by a noninducible hepatic enzyme N-acetyltransferase. Examples of drugs acetylated by this enzymatic system are: isoniazid, sulphadimidine, hydralazine, dapson and sulphapiridine. The rate of acetylation is constant in any individual but varies in different patients. People are characterized as rapid or slow acetylators with slow acetylation...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12271964

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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[Bioavailability of isoniazid in healthy volunteers--fast and slow INH acetylators].PMID 12271964Read ↗

Bioavailability factors of isoniazid in fast and slow acetylators, healthy volunteers.Semantic proximity Read ↗

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The type of isoniazid acetylation in tuberculosis patients treated at National Tuberculosis and Lung Diseases Research Institute.Semantic proximity Read ↗

Dose-escalation study of isoniazid in healthy volunteers with the rapid acetylator genotype of arylamine N-acetyltransferase 2.Semantic proximity Read ↗

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