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Article

[Bioavailability of isoniazid in healthy volunteers--fast and slow INH acetylators].

Pneumonologia i alergologia polska - 1 Jan 2002

Augustynowicz-Kopeć Ewa, Zwolska Zofia, Niemirowska-Mikulska Hanna

Abstract excerpt

The major pathway for INH metabolism is acetylation of acetyloisoniazid by a noninducible hepatic enzyme N-acetyltransferase. Examples of drugs acetylated by this enzymatic system are: isoniazid, sulphadimidine, hydralazine, dapson and sulphapiridine. The rate of acetylation is constant in any individual but varies in different patients. People are characterized as rapid or slow acetylators with slow acetylation...

Topics

Acetylation
Adult
Antitubercular Agents
Arylamine N-Acetyltransferase
Biological Availability
Humans
Isoniazid
Mycobacterium
Phenotype
Reference Values
Reproducibility of Results

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sensitivity and Specificity

Time Factors

Source

Identifiers

PMID: 12271964

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[Bioavailability of isoniazid in healthy volunteers--fast and slow INH acetylators].PMID 12271964Read ↗

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