Article
Effects of gender, AIDS, and acetylator status on intrapulmonary concentrations of isoniazid.
Antimicrobial agents and chemotherapy - 1 Aug 2002
Conte John E, Golden Jeffrey A, McQuitty Mari, Kipps Juliana, Duncan Sheila, McKenna Elaine, Zurlinden Elisabeth
Abstract excerpt
The objective of the present study was to evaluate the effects of gender, AIDS, and acetylator status on the steady-state concentrations of orally administered isoniazid in plasma and lungs. Isoniazid was administered at 300 mg once daily for 5 days to 80 adult volunteers. Subjects were assigned to eight blocks according to gender, presence or absence of AIDS, and acetylator status. Blood was obtained prior to...
Topics
- Acetylation
- Acquired Immunodeficiency Syndrome
- Adult
- Antitubercular Agents
- Body Fluids
- Bronchoalveolar Lavage Fluid
- Bronchoscopy
- Caffeine
- Epithelium
- Female
- Humans
- Isoniazid
- Lung
- Male