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Article

Paradoxical effect of isoniazid on the activity of rifampin-pyrazinamide combination in a mouse model of tuberculosis.

Antimicrobial agents and chemotherapy - 1 Oct 2009

Almeida Deepak, Nuermberger Eric, Tasneen Rokeya, Rosenthal Ian, Tyagi Sandeep, Williams Kathy, Peloquin Charles, Grosset Jacques

Abstract excerpt

To investigate the antagonism between isoniazid (INH) and rifampin (rifampicin) (RIF)-pyrazinamide (PZA) combination observed in Mycobacterium tuberculosis-infected mice, extensive pharmacokinetic studies of INH were performed and followed by experiments to assess the impact of increasing doses of INH on the antimicrobial activity of RIF-PZA combination. INH at 6.25 mg/kg of body weight produced a maximum...

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Identifiers

PMID: 19620331
DOI: 10.1128/AAC.00830-09
PMCID: PMC2764177

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Source receipt: pubmed, retrieved 7 Sept 2026.

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