Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Decreased bioavailability of rifampin and other antituberculosis drugs in patients with advanced human immunodeficiency virus disease.

Antimicrobial agents and chemotherapy - 1 Nov 2004

Gurumurthy Prema, Ramachandran Geetha, Hemanth Kumar A K, Rajasekaran S, Padmapriyadarsini C, Swaminathan Soumya, Bhagavathy S, Venkatesan P, Sekar L, Mahilmaran A, Ravichandran N, Paramesh P

Abstract excerpt

We evaluated the effects of human immunodeficiency virus (HIV) disease on pharmacokinetics of antituberculosis medications by measuring concentrations of isoniazid and rifampin in blood and of pyrazinamide and ethambutol in urine. Peak concentration and exposure were reduced for rifampin, and rapid acetylators of isoniazid had lower drug levels. HIV and HIV-tuberculosis patients who have diarrhea and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Antibiotics, Antitubercular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biological Availability

Share to Ethambutol

Share to Intestinal Absorption

Share to Isoniazid

Share to Pyrazinamide

Share to Rifampin

Source

Open in PubMed Open full text

Identifiers

PMID: 15504887
DOI: 10.1128/AAC.48.11.4473-4475.2004
PMCID: PMC525439

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Decreased bioavailability of rifampin and other antituberculosis drugs in patients with advanced human immunodeficiency virus disease.PMID 15504887Read ↗

Model-Based Assessment of Variability in Isoniazid Pharmacokinetics and Metabolism in Patients Co-Infected With Tuberculosis and HIV: Implications for a Novel Dosing Strategy.Semantic proximity Read ↗

Pharmacokinetics of efavirenz in patients on antituberculosis treatment in high human immunodeficiency virus and tuberculosis burden countries: A systematic review.Semantic proximity Read ↗

Pharmacokinetics of anti-tuberculosis drugs in children.Semantic proximity Read ↗

Age, nutritional status and INH acetylator status affect pharmacokinetics of anti-tuberculosis drugs in children.Semantic proximity Read ↗

Population Pharmacokinetics and Pharmacogenetics of Ethambutol in Adult Patients Coinfected with Tuberculosis and HIV.Semantic proximity Read ↗

Nutritional supplementation increases rifampin exposure among tuberculosis patients coinfected with HIV.Semantic proximity Read ↗

Modest but variable effect of rifampin on steady-state plasma pharmacokinetics of efavirenz in healthy African-American and Caucasian volunteers.Semantic proximity Read ↗

Paradoxical effect of isoniazid on the activity of rifampin-pyrazinamide combination in a mouse model of tuberculosis.Semantic proximity Read ↗

Paradoxically elevated efavirenz concentrations in HIV/tuberculosis-coinfected patients with CYP2B6 516TT genotype on rifampin-containing antituberculous therapy.Semantic proximity Read ↗

A study of the effects of rifabutin on isoniazid pharmacokinetics and metabolism in healthy volunteers.Semantic proximity Read ↗

A simplified method for detecting isoniazid compliance in patients receiving antituberculosis chemotherapy.Semantic proximity Read ↗

Effect of rifampicin and CYP2B6 genotype on long-term efavirenz autoinduction and plasma exposure in HIV patients with or without tuberculosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.