Analysis of the dominance of mutations in cAMP-binding sites of murine type I cAMP-dependent protein kinase in activation of kinase from heterozygous mutant lymphoma cells.

doi:10.1002/jcp.1041460112

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Article

Analysis of the dominance of mutations in cAMP-binding sites of murine type I cAMP-dependent protein kinase in activation of kinase from heterozygous mutant lymphoma cells.

Journal of cellular physiology - 1 Jan 1991

Shuntoh H, Steinberg R A

Abstract excerpt

Structural lesions in cAMP-binding sites of regulatory (R) subunit of cAMP-dependent protein kinase caused identical increases in apparent constants for cyclic nucleotide-dependent kinase activation in preparations from cells that were hemizygous or heterozygous for mutant R1 subunit expression....

Topics

Animals
Cyclic AMP
Enzyme Activation
Heterozygote
Kinetics
Lymphoma
Macromolecular Substances
Mice
Mutation
Protein Binding
Protein Kinases
Tumor Cells, Cultured

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