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Article

Analysis of the mutation to forskolin-resistance in Y1 adrenocortical tumor cells.

Endocrine research - 1 Jan 2000

Schimmer B P, Tsao J, Collie G, Wong M, Schulz P

Abstract excerpt

Forskolin reduced the plating efficiency of Y1 adrenocortical tumor cells in a concentration-dependent manner--more than 5-orders of magnitude at 10 uM forskolin and at least 6-orders of magnitude at 50 uM forskolin. This effect was related to the diterpene's ability to increase adenylate cyclase activity and adenosine 3',5'-monophosphate (cAMP) levels in Y1 cells. Stable, forskolin-resistant mutants were...

Topics

Adenylyl Cyclases
Adrenal Cortex Neoplasms
Adrenocorticotropic Hormone
Animals
Cell Line
Colforsin
Cyclic AMP
Diterpenes
Drug Resistance
Mice
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 6100248
DOI: 10.1080/07435808409036507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-6100248-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Analysis of the mutation to forskolin-resistance in Y1 adrenocortical tumor cells.PMID 6100248Read ↗

Decreased levels of guanyl nucleotide-binding regulatory protein alpha-subunits in Y1 adrenocortical tumor cell mutants resistant to forskolin.Semantic proximity Read ↗

Mutations to forskolin resistance result in loss of adrenocorticotropin receptors and consequent reductions in levels of G protein alpha-subunits.Semantic proximity Read ↗

Forskolin-resistant Y1 adrenal cell mutants are deficient in adenylyl cyclase type 4.Semantic proximity Read ↗

Expression of adenylyl cyclase-4 (AC-4) in Y1 and forskolin-resistant adrenal cells.Semantic proximity Read ↗

Molecular basis for the 3',5'-cyclic adenosine monophosphate resistance of Kin mutant Y1 adrenocortical tumor cells.Semantic proximity Read ↗

Regulation of adenylyl cyclase activity by beta-adrenergic agonists in a desensitization-resistant mutant cell line.Semantic proximity Read ↗

The causal relationship between mutations in cAMP-dependent protein kinase and the loss of adrenocorticotropin-regulated adrenocortical functions.Semantic proximity Read ↗

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Altered G protein activity in a desensitization-resistant mutant of the Y1 adrenocortical tumor cell line.Semantic proximity Read ↗

A role for guanyl nucleotide-binding regulatory protein beta- and gamma-subunits in the expression of the adrenocorticotropin receptor.Semantic proximity Read ↗

A polymorphic form of steroidogenic factor-1 is associated with adrenocorticotropin resistance in y1 mouse adrenocortical tumor cell mutants.Semantic proximity Read ↗

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