Article
Second-site mutations in cyclic AMP-sensitive revertants of a Ka mutant of S49 mouse lymphoma cells reduce the affinity of regulatory subunit of cyclic AMP-dependent protein kinase for catalytic subunit.
Journal of cellular physiology - 1 Nov 1995
Cauthron R D, Gorman K B, Symcox M M, Steinberg R A
Abstract excerpt
Ka mutants of S49 mouse lymphoma cells are generally heterozygous for expression of wild-type and mutant regulatory (R) subunits of type I alpha cyclic AMP-(cAMP)-dependent protein kinase, where the mutant R subunit has a defect in cAMP-binding to one of two intrachain cAMP-binding sites. Several...
Topics
- Animals
- Binding Sites
- Binding, Competitive
- Cyclic AMP
- Cyclic AMP-Dependent Protein Kinases
- Lymphoma
- Mice
- Mutation
- Peptide Hydrolases
- Phosphorylation