Article
A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions.
Journal of medical genetics - 1 Dec 2004
Griffin K J, Kirschner L S, Matyakhina L, Stergiopoulos S G, Robinson-White A, Lenherr S M, Weinberg F D, Claflin E S, Batista D, Bourdeau I, Voutetakis A, Sandrini F, Meoli E M, Bauer A J, Cho-Chung Y S, Bornstein S R, Carney J A, Stratakis C A
Abstract excerpt
BACKGROUND: Inactivation of the human type Ialpha regulatory subunit (RIalpha) of cyclic AMP dependent protein kinase (PKA) (PRKAR1A) leads to altered kinase activity, primary pigmented nodular adrenocortical disease (PPNAD), and sporadic adrenal and other tumours. METHODS AND RESULTS: A transgenic mouse carrying an antisense transgene for Prkar1a exon 2 (X2AS) under the control of a tetracycline responsive...
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