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Article

Binding of a 100-kDa ubiquitous factor to the human prolactin promoter is required for its basal and hormone-regulated activity.

European journal of biochemistry - 15 Nov 1992

Peers B, Nalda A M, Monget P, Voz M L, Belayew A, Martial J A

Abstract excerpt

cAMP strongly stimulates the activity of the human prolactin (hPRL) promoter. We have previously shown that two types of cis-element are required for this cAMP regulation; binding sites for the pituitary-specific factor Pit-1, and the sequence spanning nucleotides -115 to -85 (named sequence A). Sequence A contains the TGACG motif found in the consensus sequence of the cAMP-responsive element (CRE). In this...

Topics

Base Sequence
Blotting, Southern
Blotting, Western
Cells, Cultured
Cyclic AMP
Humans
Molecular Sequence Data
Mutation
Oligonucleotides
Plasmids
Prolactin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

Trans-Activators

Source

Identifiers

PMID: 1332868
DOI: 10.1111/j.1432-1033.1992.tb17389.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1332868-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Binding of a 100-kDa ubiquitous factor to the human prolactin promoter is required for its basal and hormone-regulated activity.PMID 1332868Read ↗

Transcriptional induction of the human prolactin gene by cAMP requires two cis-acting elements and at least the pituitary-specific factor Pit-1.Semantic proximity Read ↗

A conserved tissue-specific structure at a human T-cell receptor beta-chain core promoter.Semantic proximity Read ↗

The 26-amino acid beta-motif of the Pit-1beta transcription factor is a dominant and independent repressor domain.Semantic proximity Read ↗

Characterization of an up-stream promoter directing extrapituitary expression of the human prolactin geneSemantic proximity Read ↗

A Pit-1 threonine 220 phosphomimic reduces binding to monomeric DNA sites to inhibit Ras and estrogen stimulation of the prolactin gene promoter.Semantic proximity Read ↗

A two-base change in a POU factor-binding site switches pituitary-specific to lymphoid-specific gene expression.Semantic proximity Read ↗

Neuroendocrine-specific Expression of the Human Prohormone Convertase 1 GeneSemantic proximity Read ↗

A PIT-1 homeodomain mutant blocks the intranuclear recruitment of the CCAAT/enhancer binding protein alpha required for prolactin gene transcription.Semantic proximity Read ↗

The human alpha subunit glycoprotein hormone gene utilizes a unique CCAAT binding factor.Semantic proximity Read ↗

Cloning of a protein binding to the most proximal Pit-1 binding element of prolactin gene from human pituitary cDNA library.Semantic proximity Read ↗

Novel function of the transactivation domain of a pituitary-specific transcription factor, Pit-1.Semantic proximity Read ↗

Binding specificity of cyclic adenosine 3',5'-monophosphate-responsive element (CRE)-binding proteins and activating transcription factors to naturally occurring CRE sequence variants.Semantic proximity Read ↗

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