Article
Binding specificity of cyclic adenosine 3',5'-monophosphate-responsive element (CRE)-binding proteins and activating transcription factors to naturally occurring CRE sequence variants.
Molecular endocrinology (Baltimore, Md.) - 1 Oct 1991
Drust D S, Troccoli N M, Jameson J L
Abstract excerpt
The human glycoprotein hormone alpha gene contains a palindromic cAMP-responsive element (CRE), TGACGTCA, which is critical for both basal and cAMP-stimulated expression. Members of the CRE-binding protein (CREB)/activating transcription factor transcription family as well as members of the Jun/Fos family have been shown to bind to this sequence. In nonprimate species, the alpha gene contains a variant of the CRE...
Topics
- 8-Bromo Cyclic Adenosine Monophosphate
- Animals
- Base Sequence
- Binding Sites
- Cell Line
- Cyclic AMP Response Element-Binding Protein
- DNA-Binding Proteins
- Genetic Variation
- Humans
- Immunoblotting