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Article

Novel function of the transactivation domain of a pituitary-specific transcription factor, Pit-1.

The Journal of biological chemistry - 22 Nov 2002

Kishimoto Masahiko, Okimura Yasuhiko, Yagita Kazuhiro, Iguchi Genzo, Fumoto Mariko, Iida Keiji, Kaji Hidesuke, Okamura Hitoshi, Chihara Kazuo

Abstract excerpt

Pit-1 stimulates the expression of growth hormone, prolactin, and thyrotropin beta subunit genes. Consequently, abnormality of the Pit-1 gene results in combined pituitary hormone deficiency (CPHD). In this study, we analyzed the function of Pit-1 with a mutation (proline to leucine at codon 24) in the transactivation domain, P24L, which has a normal POU domain important for binding to DNA, because this mutation...

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Identifiers

PMID: 12200420
DOI: 10.1074/jbc.M202991200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A PROP1-binding factor, AES cloned by yeast two-hybrid assay represses PROP1-induced Pit-1 gene expression.Semantic proximity Read ↗

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