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Article

The 26-amino acid beta-motif of the Pit-1beta transcription factor is a dominant and independent repressor domain.

Molecular endocrinology (Baltimore, Md.) - 1 Sept 2009

Jonsen Matthew D, Duval Dawn L, Gutierrez-Hartmann Arthur

Abstract excerpt

The POU-homeodomain transcription factor Pit-1 governs the pituitary cell-specific expression of Pit-1, GH, prolactin (PRL), and TSHbeta genes. Alternative splicing generates Pit-1beta, which contains a 26-amino acid beta-domain inserted at amino acid 48, in the middle of the Pit-1 transcription activation domain (TAD). Pit-1beta represses GH, PRL, and TSHbeta promoters in a pituitary-specific manner, because...

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Source

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Identifiers

PMID: 19556346
DOI: 10.1210/me.2008-0137
PMCID: PMC2737555

Genes

PRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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