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Article

A conserved tissue-specific structure at a human T-cell receptor beta-chain core promoter.

Molecular and cellular biology - 1 Aug 1997

Halle J P, Haus-Seuffert P, Woltering C, Stelzer G, Meisterernst M

Abstract excerpt

The T-cell receptor (TCR) beta-chain promoters have been characterized as nonstructured basal promoters that carry a single conserved ubiquitous cyclic AMP-responsive element. Our investigation of the human TCR beta gene uncovers a surprisingly complex and tissue-specific structure at the TCR Vbeta 8.1 promoter. The core of the promoter (positions -42 to +11) is recognized by the lymphoid cell-specific...

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Identifiers

PMID: 9234679
DOI: 10.1128/MCB.17.8.4220
PMCID: PMC232275

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