Article
A conserved tissue-specific structure at a human T-cell receptor beta-chain core promoter.
Molecular and cellular biology - 1 Aug 1997
Halle J P, Haus-Seuffert P, Woltering C, Stelzer G, Meisterernst M
Abstract excerpt
The T-cell receptor (TCR) beta-chain promoters have been characterized as nonstructured basal promoters that carry a single conserved ubiquitous cyclic AMP-responsive element. Our investigation of the human TCR beta gene uncovers a surprisingly complex and tissue-specific structure at the TCR Vbe...
Topics
- Base Sequence
- Binding Sites
- CD4-Positive T-Lymphocytes
- Consensus Sequence
- Conserved Sequence
- DNA
- HeLa Cells
- Humans
- Jurkat Cells
- Molecular Sequence Data
- Mutation
- Organ Specificity
- Promoter Regions, Genetic
- Receptors, Antigen, T-Cell, alpha-beta
- Transcription Factors
- Transcriptional Activation