Article
A two-base change in a POU factor-binding site switches pituitary-specific to lymphoid-specific gene expression.
Genes & development - 1 Jan 1990
Elsholtz H P, Albert V R, Treacy M N, Rosenfeld M G
Abstract excerpt
The structurally related POU homeo domain proteins Pit-1 and Oct-2 activate pituitary- and lymphoid-specific transcription, respectively, by binding to similar AT-rich motifs in their target genes. In this study we identify bases critical for recognition and activation by Pit-1 and examine how small differences in Pit-1 and Oct-2-binding sites can impart differential transcriptional responses in pituitary and...
Topics
- Animals
- B-Lymphocytes
- Base Sequence
- Binding Sites
- Binding, Competitive
- Cell Line
- Gene Expression Regulation
- Genes, Immunoglobulin
- Molecular Sequence Data
- Mutation
- Pituitary Gland