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The Herpes Simplex Virus ICP0 RING Finger Domain Inhibits IRF3- and IRF7-Mediated Activation of Interferon-Stimulated Genes

27 Jan 2004

Abstract excerpt

Virus infection induces a rapid cellular response in cells characterized by the induction of interferon. While interferon itself does not induce an antiviral response, it activates a number of interferon-stimulated genes that collectively function to inhibit virus replication and spread. Previously, we and others reported that herpes simplex virus type 1 (HSV-1) induces an interferon -independent antiviral...

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PMID: 14747533
DOI: 10.1128/jvi.78.4.1675-1684.2004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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