Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of the functions of herpes simplex virus type 1 regulatory protein ICP0 that are critical for lytic infection and derepression of quiescent viral genomes.

Journal of virology - 1 May 2009

Everett Roger D, Parsy Marie-Laure, Orr Anne

Abstract excerpt

Herpes simplex virus type 1 (HSV-1) immediate-early regulatory protein ICP0 is important for stimulating the initiation of the lytic cycle and efficient reactivation of latent or quiescent infection. Extensive investigation has suggested several potential functions for ICP0, including interference in the interferon response, disruption of functions connected with PML nuclear bodies (ND10), and inhibition of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Viral
Share to Genetic Complementation Test

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Herpes Simplex

Share to Herpesvirus 1, Human

Share to Immediate-Early Proteins

Share to Protein Interaction Domains and Motifs

Share to Transduction, Genetic

Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 19264778
DOI: 10.1128/JVI.02593-08
PMCID: PMC2682082

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of the functions of herpes simplex virus type 1 regulatory protein ICP0 that are critical for lytic infection and derepression of quiescent viral genomes.PMID 19264778Read ↗

Recruitment of Herpes Simplex Virus Type 1 Transcriptional Regulatory Protein ICP4 into Foci Juxtaposed to ND10 in Live, Infected CellsSemantic proximity Read ↗

ICP0 enables and monitors the function of D cyclins in herpes simplex virus 1 infected cells.Semantic proximity Read ↗

ICP0, a regulator of herpes simplex virus during lytic and latent infectionSemantic proximity Read ↗

During its nuclear phase the multifunctional regulatory protein ICP0 undergoes proteolytic cleavage characteristic of polyproteins.Semantic proximity Read ↗

Herpes simplex virus-infected cell protein 0 blocks the silencing of viral DNA by dissociating histone deacetylases from the CoREST-REST complex.Semantic proximity Read ↗

Replication of ICP0-null mutant herpes simplex virus type 1 is restricted by both PML and Sp100.Semantic proximity Read ↗

Intracellular localization of the herpes simplex virus type 1 major transcriptional regulatory protein, ICP4, is affected by ICP27.Semantic proximity Read ↗

Activities of ICP0 Involved in the Reversal of Silencing of Quiescent Herpes Simplex Virus 1Semantic proximity Read ↗

Components of Promyelocytic Leukemia Nuclear Bodies (ND10) Act Cooperatively To Repress Herpesvirus InfectionSemantic proximity Read ↗

The Replication Defect of ICP0-Null Mutant Herpes Simplex Virus 1 Can Be Largely Complemented by the Combined Activities of Human Cytomegalovirus Proteins IE1 and pp71Semantic proximity Read ↗

Herpes simplex virus 1 alpha regulatory protein ICP0 functionally interacts with cellular transcription factor BMAL1Semantic proximity Read ↗

Functional Interaction between Class II Histone Deacetylases and ICP0 of Herpes Simplex Virus Type 1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.