Article
Enhanced expression of myogenic regulatory genes in aging skeletal muscle.
Experimental cell research - 1 Nov 1995
Musarò A, Cusella De Angelis M G, Germani A, Ciccarelli C, Molinaro M, Zani B M
Abstract excerpt
MyoD, myogenin, myf-5, and MRF4, belonging to the family of basic helix-loop-helix (bHLH) myogenic regulatory factors (MRFs), control muscle cell differentiation, in concert with other transcription factors such as MEF-2, yet their role in age-related skeletal muscle alteration has not been addressed. We here report that MyoD and myogenin transcripts are expressed at high levels in the hind limb muscles of...
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