Article
Low frequency of p53 mutations observed in a diverse collection of primary hepatocellular carcinomas.
Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 1992
Buetow K H, Sheffield V C, Zhu M, Zhou T, Shen F M, Hino O, Smith M, McMahon B J, Lanier A P, London W T
Abstract excerpt
Recent studies of the p53 tumor suppressor locus (designated TP53) in primary hepatocellular carcinoma (PHC) have identified a high frequency of codon 249 mutations. Due to the geographic location from which the samples were obtained and the substitution observed, the mutation was suggested to be attributable to aflatoxin B1 (AFB1) exposure. To determine the generality of this phenomenon, we have examined PHC...
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