Article
Low frequency of p53 mutations observed in a diverse collection of primary hepatocellular carcinomas.
Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 1992
Buetow K H, Sheffield V C, Zhu M, Zhou T, Shen F M, Hino O, Smith M, McMahon B J, Lanier A P, London W T
Abstract excerpt
Recent studies of the p53 tumor suppressor locus (designated TP53) in primary hepatocellular carcinoma (PHC) have identified a high frequency of codon 249 mutations. Due to the geographic location from which the samples were obtained and the substitution observed, the mutation was suggested to be...
Topics
- Base Sequence
- Carcinoma, Hepatocellular
- DNA, Neoplasm
- Genes, p53
- Humans
- Liver Neoplasms
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction