Article
Mutations at codon 249 of p53 gene in human hepatocellular carcinomas from Tongan, China.
Mutation research - 19 Nov 1997
Yang M, Zhou H, Kong R Y, Fong W F, Ren L Q, Liao X H, Wang Y, Zhuang W, Yang S
Abstract excerpt
Codon 249 (exon 7) of the putative tumor suppressor gene p53 is a mutational hot-spot for hepatocellular carcinoma (HCC) but not other tumors. DNA samples from primary HCC patients from Tongan, an area of high HCC incidence in China (> 40 per 100,000 population), were analyzed for specific mutati...
Topics
- Adult
- Carcinoma, Hepatocellular
- China
- Codon
- Deoxyribonucleases, Type II Site-Specific
- Female
- Genes, p53
- Hepatitis B Surface Antigens
- Humans
- Liver Neoplasms
- Male
- Middle Aged
- Mutation
- Polymerase Chain Reaction
- Restriction Mapping
- Risk Factors
- Sequence Analysis, DNA
- alpha-Fetoproteins