Article
Mutations at codon 249 of p53 gene in human hepatocellular carcinomas from Tongan, China.
Mutation research - 19 Nov 1997
Yang M, Zhou H, Kong R Y, Fong W F, Ren L Q, Liao X H, Wang Y, Zhuang W, Yang S
Abstract excerpt
Codon 249 (exon 7) of the putative tumor suppressor gene p53 is a mutational hot-spot for hepatocellular carcinoma (HCC) but not other tumors. DNA samples from primary HCC patients from Tongan, an area of high HCC incidence in China (> 40 per 100,000 population), were analyzed for specific mutations in codon 249 of the p53 gene using polymerase chain reaction (PCR)/restriction-digest methods and direct DNA...
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