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Article

Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A.

Molecular and cellular biology - 1 Nov 1992

Virshup D M, Russo A A, Kelly T J

Abstract excerpt

The catalytic subunit of protein phosphatase 2A (PP2Ac) stimulates the initiation of replication of simian virus 40 DNA in vitro by dephosphorylating T antigen at specific phosphoserine residues (K. H. Scheidtmann, D. M. Virshup, and T. J. Kelly, J. Virol. 65:2098-2101, 1991). To better define the biochemical mechanism responsible for this stimulation, we investigated the effect of PP2Ac on the interaction of T...

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Identifiers

PMID: 1328866
DOI: 10.1128/mcb.12.11.4883-4895.1992
PMCID: PMC360421

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