Article
The activity of topoisomerase I is modulated by large T antigen during unwinding of the SV40 origin.
The Journal of biological chemistry - 7 Aug 1998
Simmons D T, Roy R, Chen L, Gai D, Trowbridge P W
Abstract excerpt
When simian virus 40 (SV40) large T antigen binds to the virus origin of replication, it forms a double hexamer that functions as a helicase to unwind the DNA bidirectionally. We demonstrate in this report that T antigen can unwind and release an origin DNA single strand of less than full length...
Topics
- Antigens, Viral, Tumor
- DNA Helicases
- DNA Replication
- DNA Topoisomerases, Type I
- DNA, Viral
- Humans
- Mutation
- Nucleic Acid Conformation
- Replication Origin
- Sequence Analysis, DNA
- Simian virus 40