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Article

Three domains in the simian virus 40 core origin orchestrate the binding, melting, and DNA helicase activities of T antigen.

Journal of virology - 1 Feb 1990

Parsons R, Anderson M E, Tegtmeyer P

Abstract excerpt

The simian virus 40 (SV40) core origin of replication consists of three functional domains. The sequence 5'-CACTACTTCTGGAATAG-3' with an imperfect inverted repeat (underlined), a palindrome with four 5'-GAGGC-3' pentanucleotide repeats, and a 17-base-pair A + T-rich segment. We have been able to assign primary functions to each domain. Remarkably, SV40 large T antigen melted the inverted repeat domain in the...

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Identifiers

PMID: 2153220
DOI: 10.1128/JVI.64.2.509-518.1990
PMCID: PMC249138

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