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Article

The DNA-binding domain of simian virus 40 tumor antigen has multiple functions.

Journal of virology - 1 Dec 1993

Wun-Kim K, Upson R, Young W, Melendy T, Stillman B, Simmons D T

Abstract excerpt

The DNA-binding domain of simian virus 40 tumor antigen has been previously shown to participate in a number of different activities. Besides being involved in binding to sequences at the viral replication origin, this domain appears to be required for nonspecific DNA binding, for structurally distorting origin DNA (melting and untwisting), and possibly for oligomerization of the protein into hexamers and double...

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Source

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Identifiers

PMID: 8230479
DOI: 10.1128/JVI.67.12.7608-7611.1993
PMCID: PMC238227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The DNA-binding domain of simian virus 40 tumor antigen has multiple functions.PMID 8230479Read ↗

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Structure of the origin‐binding domain of simian virus 40 large T antigen bound to DNASemantic proximity Read ↗

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Identification of simian virus 40 T-antigen residues important for specific and nonspecific binding to DNA and for helicase activity.Semantic proximity Read ↗

Model for T-antigen-dependent melting of the simian virus 40 core origin based on studies of the interaction of the beta-hairpin with DNA.Semantic proximity Read ↗

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Simian virus 40 T-antigen DNA helicase is a hexamer which forms a binary complex during bidirectional unwinding from the viral origin of DNA replicationSemantic proximity Read ↗

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