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Article

Insights into hRPA32 C-terminal domain--mediated assembly of the simian virus 40 replisome.

Nature structural & molecular biology - 1 Apr 2005

Arunkumar Alphonse I, Klimovich Vitaly, Jiang Xiaohua, Ott Robert D, Mizoue L, Fanning Ellen, Chazin Walter J

Abstract excerpt

Simian virus 40 (SV40) provides a model system for the study of eukaryotic DNA replication, in which the viral protein, large T antigen (Tag), marshals human proteins to replicate the viral minichromosome. SV40 replication requires interaction of Tag with the host single-stranded DNA-binding protein, replication protein A (hRPA). The C-terminal domain of the hRPA32 subunit (RPA32C) facilitates initiation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15793585
DOI: 10.1038/nsmb916
PMCID: PMC2600586

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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