Article
A TEF-1-independent mechanism for activation of the simian virus 40 (SV40) late promoter by mutant SV40 large T antigens.
Journal of virology - 1 Jun 1995
Casaz P, Rice P W, Cole C N, Hansen U
Abstract excerpt
Simian virus 40 (SV40) large tumor antigen (T antigen) stimulates the activity of the SV40 late promoter and a number of cellular and other viral promoters. We have characterized the ability of T antigens with mutations in the DNA-binding domain and within the N-terminal 85 residues to activate the SV40 late promoter. T antigens lacking both nonspecific and sequence-specific DNA-binding activities were able to...
Topics
- Antigens, Polyomavirus Transforming
- Cell Line
- DNA-Binding Proteins
- Mutation
- Nuclear Proteins
- Phenotype
- Promoter Regions, Genetic
- Simian virus 40
- TEA Domain Transcription Factors
- Transcription Factors