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Article

Analysis of the heterogeneity of the biological responses to native and mutant human interleukin-6.

Journal of leukocyte biology - 1 Oct 1992

Krakauer T, Snouwaert J N, Fowlkes D M, Krakauer H

Abstract excerpt

The structure-function relationships of the biological activities of mutant varieties of the pleiotropic cytokine interleukin-6 (human) were measured by three assays: induction of immunoglobulin M (IgM) secretion from an Epstein-Barr virus-transformed human B cell line and induction of fibrinogen secretion from either a human hepatoma cell line or a rat hepatoma cell line. The biological effects of the cytokine...

Topics

Animals
B-Lymphocytes
Cell Transformation, Viral
Herpesvirus 4, Human
Humans
Immunoglobulin M
Interleukin-6
Kinetics
Liver
Liver Neoplasms, Experimental
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Stimulation, Chemical

Structure-Activity Relationship

Tumor Cells, Cultured

Source

Identifiers

PMID: 1328443
DOI: 10.1002/jlb.52.4.415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1328443-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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