Leucine-58 in the putative 5th helical region of human interleukin (IL)-6 is important for activation of the IL-6 signal transducer, gp130.

doi:10.1016/0014-5793(95)00741-q

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Article

Leucine-58 in the putative 5th helical region of human interleukin (IL)-6 is important for activation of the IL-6 signal transducer, gp130.

FEBS letters - 7 Aug 1995

de Hon F D, Klaasse Bos H K, Ebeling S B, Grötzinger J, Kurapkat G, Rose-John S, Aarden L A, Brakenhoff J P

Abstract excerpt

A model of the tertiary structure of human IL-6, derived from the crystal-structure of granulocyte-colony stimulating factor, reveals a 5th helical region in the loop between the first and second alpha-helix. To investigate the importance of this region for biological activity of IL-6, residues Glu-52, Ser-53, Ser-54, Lys-55, Glu-56, Leu-58, and Glu-60 were individually replaced by alanine. IL-6.Leu-58Ala...

Topics

Amino Acid Sequence
Animals
Antigens, CD
Base Sequence
Binding, Competitive
Cell Division
Cytokine Receptor gp130
Humans
Hybridomas
Interleukin-6
Leucine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Glycoproteins

Mice

Models, Molecular

Molecular Sequence Data

Mutation

Protein Structure, Secondary

Protein Structure, Tertiary

Source

Open in PubMed

Identifiers

PMID: 7649255
DOI: 10.1016/0014-5793(95)00741-q

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7649255-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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