Article
Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens.
The EMBO journal - 1 Nov 1992
Crook T, Vousden K H
Abstract excerpt
Primary human papillomavirus (HPV) positive anogenital cancers normally develop without somatic mutation within the p53 gene. In this study, however, we have identified p53 point mutations in metastases arising from HPV positive cervical carcinomas, suggesting that acquisition of p53 mutation may play a role in the progression of some HPV associated primary cancers. p53 mutants identified in anogenital cancers...
Topics
- Animals
- Cell Line
- Codon
- Exons
- Female
- Genes, Viral
- Genes, p53
- Humans
- Mutation
- Neoplasm Metastasis
- Neoplasm Staging
- Oncogene Proteins, Viral