Article
p53 mutations are rare events in recurrent cervical cancer.
Journal of molecular medicine (Berlin, Germany) - 1 Jun 2001
Denk C, Butz K, Schneider A, Dürst M, Hoppe-Seyler F
Abstract excerpt
Mutations of the p53 gene have been shown to be associated with aggressive growth behavior and increased recurrence rates for certain tumors. Primary cervical cancers contain oncogenic human papillomaviruses (HPV) in more than 90% of cases and usually possess wild-type p53 alleles. Cervical cancer cells contain detectable levels of functional p53 protein despite of the expression of the HPV E6 protein, which can...
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