Article
Clustering of discrete cell properties essential for tumorigenicity and metastasis. III. Dissociation of the properties in N-ras-transfected RSV-SR-transformed cells.
International journal of cancer - 30 Jul 1992
Deichman G I, Topol L Z, Kluchareva T E, Matveeva V A, Zakamaldina T A, Uvarova E N, Tatosyan A G
Abstract excerpt
We have previously shown that RSV-SR-transformed hamster cells acquire high resistance to H2O2, i.e. the cytotoxic product of activated macrophages (H2O2R) and that they begin to secrete PGE (PGES), thus inactivating the CTA of NK cells. Among normal cells, the same phenotype is expressed in acti...
Topics
- Animals
- Avian Sarcoma Viruses
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Cricetinae
- Cytotoxicity, Immunologic
- Drug Resistance
- Embryo, Mammalian
- Genes, ras
- Humans
- Hydrogen Peroxide
- Kanamycin Kinase
- Killer Cells, Natural
- Lung Neoplasms